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4-AcO, or “synthetic mushrooms,” is frequently combined with psychedelics and cannabis. Although poly-drug mixes can still be unpredictable, intense, and open up more potential for harm. And so, like with any psychedelic, it’s best to get to know the substance on its own before mixing it with other entheogens.
Mixing cannabis and 4-AcO-DMT seems to be the most common combo, and like mixing cannabis with other psychedelics, the main effect is an intensifying of the experience, especially the visual and cognitive effects of the 4-AcO. Psychonaut Wiki warns that this interaction can also intensify anxiety and confusion, which Cindy reported in our survey.
WARNING: Certainly his product is not for human or veterinary use.
IKown to interact with some pharmaceuticals e.g. 4-AcO, Lithium, tramadol, and stimulants like Adderall (but also cocaine and meth). In the case of Lithium, mixing increase the risk of psychosis and seizures. Tramadol could also increase the risk of a seizure in susceptible individuals. When it comes to stimulants, the risk is that they could increase the risk of severe anxiety.