Buy Midazolam(100ml) 1mg/ml Injection Online
To begin with, Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. As such, It belongs to a class of drugs called benzodiazepines. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Since, Midazolam is available by oral, rectal, intranasal, intramuscular (IM), and intravenous (IV) routes. Certainly, it has been used in various biomedical applications, including dentistry, cardiac surgery. And also, endoscopic procedures as pre-anesthetic medication, and as an adjunct to local anesthesia.
Initially approved by the US FDA in 1985 with approved various indications since. However, in Late 2018, the intramuscular preparation approved by the FDA. Precisely for treatment of adult status epilepticus. May 2019, the nasal spray of midazolam approved. Actually, Midazolams a schedule IV drug in the United States. Low abuse and dependence risk potential.
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Indication of midazolam
- Indicated for promoting preoperative sedation, anxiolysis, anesthesia induction, or amnesia.12
- Indicated for the treatment of status epilepticus in adults.Label
- Nasal. Abovel all; Indicated for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (i.e., seizure clusters, acute repetitive seizures) that are distinct from a patient’s usual seizure pattern in patients with epilepsy 12 years of age and older.
Mechanism of action
Therefore, the actions of benzodiazepines such as midazolam are mediated through the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which is one of the major inhibitory neurotransmitters in the central nervous system. in conclusion, enzodiazepines increase the activity of GABA, thereby producing a sedating effect, relaxing skeletal muscles, and inducing sleep, anesthesia, and amnesia.